Day 1 :
Baylor College of Medicine, USA
Time : 09:45-10:25
Nathan S Bryan is an international expert on nitrate, nitrite and nitric oxide. He has made many seminal discoveries in the field of nitric oxide. These discoveries and findings have unveiled many beneficial effects of nitrite in the treatment and prevention of human disease and may provide the basis for new preventive or therapeutic strategies in diseases associated with NO insufficiency and new guidelines for optimal health. He has published a number of highly cited papers and authored or edited 5 books. He is also an inventor on multiple issued patents.
There are now indisputable health benefits of nitrite when administered in a clinical setting for specific diseases. Most of the published reports identify the production of nitric oxide (NO) as the mechanism of action for nitrite. Basic science as well as clinical studies demonstrates nitrite and/or nitrate can restore NO homeostasis as an endothelium independent source of NO that may be a redundant system for endogenous NO production. Nitrate must first be reduced to nitrite by oral commensal bacteria and then nitrite further reduced to NO along the physiological oxygen gradient. Despite decades of rigorous research on its safety and efficacy as a curing agent, sodium nitrite and nitrate are still regarded by many as a toxic undesirable food additive. However, research within the biomedical science community has revealed enormous therapeutic benefits of nitrite and nitrate that are currently being developed as novel therapies for conditions associated with nitric oxide insufficiency. This presentation will highlight the fundamental biochemistry of nitrite and nitrate in human physiology and provide evidence that nitrite and nitrate be considered essential nutrients. Foods or diets enriched with nitrite can have profound positive health benefits.
La Trobe University, Australia
Keynote: Inclusion of molasses in a high fat, high sugar diet prevents the development of obesity in C57BL6/J mice
Time : 10:45-11:25
Markandeya Jois has expertise in the prevention and treatment of obesity and metabolic syndrome. His research in this area employs animal models as well as clinical trials with particular emphasis on the role of food plants in disease prevention
Statement of the problem: One of the contributing factors for the current epidemic of obesity is the increased consumption of added sugar in the diet. Sugarcane accounts for 80% of the sugar production. Molasses, a byproduct of sugar production from sugarcane, is known rich in many bioactive compounds including flavonoids and phenylpropanoids. Here we show that inclusion of molasses in a high fat, high sugar diet protects mice from developing obesity. Methods: Thirty-six 6-wk old male mice were assigned to one of 3 groups. Each group was fed either a high fat, high sugar diet (HFC), a HFC diet containing 10% molasses replacing 5% sugar and 5% cellulose (Mol-Sugar) or a HFC diet containing 10% molasses replacing 5% starch and 5% cellulose (Mol-Starch). Mice were maintained on these diets for 14 weeks and food intake and bodyweights were monitored weekly. At weeks 7 and 14, randomly selected mice were culled and body composition, plasma metabolites and tissue gene expression were measured Findings: Molasses groups gained significantly less bodyweight and had lower body fat. The effects of molasses on body fat content was greater in the Mol-Sugar group. Reduced body fat in the molasses groups were associated with an up-regulation of SIK2 gene expression and a down-regulation of ATF3 gene expression in adipose tissue. Circulating adiponectin levels were also elevated in the molasses groups. Conclusion & Significance: Sugarcane molasses contain anti-obesity compounds and addition of these compounds to sugar containing food products may help prevent the development of obesity.
Saveetha Medical College, India
Time : 11:25-12:05
Krishnan Vengadaragava Chary did his post graduation from prestigious Stanley Medical College. He is an eminent pharmacologist , well known for his teaching skills in college and PG entrance coaching. He has won many prizes including a best poster in IPS conference at Bangalore. He is research coordinator of Saveetha Medical College and consultant for few ethics committee and contract research organization at Chennai. He has five SCOPUS , PUBMED indexed publications. He is reviewer of Science and Engineering Research Board ( SERB), Govt of India and in few biomedical journals. He has authored a chapter of Pharmacology in book entitled TARGET JIPMER , 1st ed, 2013 published by Wolters Kluwer