Nathan S Bryan
Baylor College of Medicine, USA
Title: Dietary nitrite and nitrate: From menace to marvel
Biography
Biography: Nathan S Bryan
Abstract
There are now indisputable health benefits of nitrite when administered in a clinical setting for specific diseases. Most of the published reports identify the production of nitric oxide (NO) as the mechanism of action for nitrite. Basic science as well as clinical studies demonstrates nitrite and/or nitrate can restore NO homeostasis as an endothelium independent source of NO that may be a redundant system for endogenous NO production. Nitrate must first be reduced to nitrite by oral commensal bacteria and then nitrite further reduced to NO along the physiological oxygen gradient. Despite decades of rigorous research on its safety and efficacy as a curing agent, sodium nitrite and nitrate are still regarded by many as a toxic undesirable food additive. However, research within the biomedical science community has revealed enormous therapeutic benefits of nitrite and nitrate that are currently being developed as novel therapies for conditions associated with nitric oxide insufficiency. This presentation will highlight the fundamental biochemistry of nitrite and nitrate in human physiology and provide evidence that nitrite and nitrate be considered essential nutrients. Foods or diets enriched with nitrite can have profound positive health benefits.